Richter, Hans G. F.; Adams, D. R.; Benardeau, A.; Bickerdike, M. J.; Bentley, J. M.; Blench, T. J.; Cliffe, I. A.; Dourish, C.; Hebeisen, P.; Kennett, G. A.; Knight, A. R.; Malcolm, C. S.; Mattei, P.; Misra, A.; Mizrahi, J.; Monck, N. J. T.; Plancher, J.-M.; Roever, S.; Roffey, J. R. A.; Taylor, S.; Vickers, S. P. published the artcile< Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT2C receptor agonists>, SDS of cas: 112-63-0, the main research area is pyridopyrrolopyrazine preparation 5HT agonist.
Further lead optimization efforts on previously described 1,2,3,4,10,10a-hexahydro-1H-pyrazino[1,2-a]indoles led to the new class of 5,5a,6,7,8,9-hexahydro-pyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazines culminating in the discovery of (5aR,9R)-2-[(cyclopropylmethoxy)methyl]-5,5a,6,7,8,9-hexahydro-9-methyl-pyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazine as a potent, full 5-HT2C receptor agonist with an outstanding selectivity profile and excellent hERG and phospholipidosis properties.
Bioorganic & Medicinal Chemistry Letters published new progress about 5-HT2C receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics