Zhang, Yan; Lv, Jie; Zhang, Suqing; Yang, Hanxi; Shen, Jingshan; Du, Changsheng; Jiang, Xiangrui; Aisa, Haji A. published the artcile< Synthesis and biological evaluation of artemisinin derivatives as potential MS agents>, Product Details of C19H34O2, the main research area is artemisinin derivative anti multiple sclerosis agent; Artemisinin derivatives; EAE; IFN-γ/IL-17A; Multiple sclerosis; Th1/Th17.
In this paper, a series of artemisinin derivatives were synthesized and evaluated. Studies have shown that IFN-γ produced by Th1 CD4+ T cells and IL-17A secreted by Th17 CD4+ T cells played critical roles in the treatment of multiple sclerosis. We used different concentrations of artemisinin derivatives to inhibit Th1 / Th17 differentiation in naive CD4+ T cells and to characterize IFN-γ / IL-17A in in vitro experiments The preliminary screening results showed that ester compound 5 (I) exhibited obvious inhibitory activities on Th1 and Th17 (IFN-γ decreased from 41% to 3% and IL-17A decreased from 24% to 8% at the concentration of 10 nM to 10μM), and carbamate compounds also had obvious inhibitory activities against Th17 at high concentration Moreover, we investigated the effect of compound 5 on myelin oligodendrocyte glycoprotein (MOG)-induced mice exptl. autoimmune encephalomyelitis (EAE) model in vivo. 100 mg/kg compound 5 effectively reduced the disease severity of EAE compared with the vehicle group. This research revealed that compound 5 could be a promising avenue as potential MS inhibitor.
Bioorganic & Medicinal Chemistry Letters published new progress about Anti-multiple sclerosis agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics