Bekele, Tefsit; Shah, Meha H.; Wolfer, Jamison; Abraham, Ciby J.; Weatherwax, Anthony; Lectka, Thomas published the artcile< Catalytic, Enantioselective [4 + 2]-Cycloadditions of Ketene Enolates and o-Quinones: Efficient Entry to Chiral, α-Oxygenated Carboxylic Acid Derivatives>, Safety of (R)-Methyl 2-hydroxybutanoate, the main research area is cinchona alkaloid catalyst enantioselective cycloaddition quinone ketene enolate.
The authors report catalytic, enantioselective [4 + 2]-cycloadditions of o-quinones with ketene enolates (derived from readily available acid chlorides) using cinchona alkaloid derivatives as catalysts to produce products in high enantiomeric excess (ee) and good to excellent yields. The thermodn. driving force for these reactions is due in part to the restoration of aromaticity to the products. The resulting chiral, bicycloadducts, e.g. I, can be synthetically manipulated in a variety of useful ways, for example to provide a flexible synthesis of α-oxygenated carboxylic acid derivatives
Journal of the American Chemical Society published new progress about [4+2] Cycloaddition reaction. 73349-07-2 belongs to class esters-buliding-blocks, and the molecular formula is C5H10O3, Safety of (R)-Methyl 2-hydroxybutanoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics