Ono, Masahiro; Wilson, Alan; Nobrega, Jose; Westaway, David; Verhoeff, Paul; Zhuang, Zhi-Ping; Kung, Mei-Ping; Kung, Hank F. published the artcile< 11C-labeled stilbene derivatives as Aβ-aggregate-specific PET imaging agents for Alzheimer's disease>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is carbon 11 stilbene preparation PET Alzheimer amyloid plaque.
A series of stilbene derivatives as potential diagnostic imaging agents targeting amyloid plaques in Alzheimer’s disease (AD) were synthesized and evaluated. The syntheses of the stilbenes were successfully achieved by a simple Wadsworth-Emmons reaction between di-Et (4-nitrobenzyl)phosphonate and 4-methoxybenzaldehyde. 4-N,N-dimethylamino-4′-methyoxy and the corresponding 4-N-monomethylamino-, 4′-hydroxy stilbenes showed good binding affinities towards Aβ aggregates in vitro (Ki < 10 nM). The 11C labeled 4-N-methylamino-4'-hydroxystilbene, [11C]4, was prepared by 11C methylation of 4-amino-4'-hydroxystilbene. The [11C]4 displayed a moderate lipophilicity (log P = 2.36), and showed a very good brain penetration and washout from normal rat brain after an iv injection. In vitro autoradiog. of transgenic AD mouse brain sections showed a high specific labeling of β-amyloid plaques, whereas the control sections showed no binding. Taken together the data suggest that a relatively simple stilbene derivative, [11C]4, N-[11C]methylamino-4'-hydroxystilbene, may be useful as a positron emission tomog. (PET) imaging agent for mapping Aβ plaques in the brain of patients with Alzheimer's disease. Nuclear Medicine and Biology published new progress about Alzheimer disease. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics