Zhang, Qing-Wei; Jiang, Ling; Wang, Guan; Li, Jian-Qi published the artcile< Design, synthesis and neuroprotective effects of Fenazinel derivatives>, COA of Formula: C19H34O2, the main research area is fenazinel preparation neuroprotective activity.
In search of novel neuroprotective agents with higher potency and lower hERG liability, a series of novel Fenazinel derivatives I [R = {2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl}methyl, 2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl, (phenylcarbamoyl)methyl, etc.] was designed and synthesized, among which compounds containing amide moiety I [R = (phenylcarbamoyl)methyl, [(pyridin-4-yl)carbamoyl]methyl, [(5-methyl-1,3,4-thiadiazol-2-yl)carbamoyl]methyl] exhibited good neuroprotective effects in vitro and in vivo. Especially, the representative compound I [R = [(pyridin-4-yl)carbamoyl]methyl] showed lower activity in a patch clamp hERG K+ ion channel screen and could be considered as a lead compound for further development. These findings provided an alternative approach to the development of drugs more potent than Fenazinel for the intervention of ischemic stroke.
Chinese Chemical Letters published new progress about Heterocyclic compounds, nitrogen Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics