Kawashiri, Takehiro; Miyagi, Anna; Shimizu, Shiori; Shigematsu, Nao; Kobayashi, Daisuke; Shimazoe, Takao published the artcile< Dimethyl fumarate ameliorates chemotherapy agent-induced neurotoxicity in vitro>, Product Details of C19H34O2, the main research area is neurodegeneration dimethyl fumarate chemotherapy; Chemotherapy agents; Dimethyl fumarate; Neurotoxicity; Nuclear factor-erythroid-2-related factor 2 (Nrf2); Oxaliplatin.
Chemotherapy agents such as oxaliplatin, cisplatin, paclitaxel, and bortezomib frequently cause severe peripheral neuropathy and there is currently no effective strategy to prevent this. Di-Me fumarate (DMF) is a new oral drug for the treatment of multiple sclerosis, and has neuroprotective effects via up-regulation of the nuclear factor-erythroid-2-related factor 2 (Nrf2)-dependent antioxidant response. In this study, we investigated the effect of DMF on chemotherapy agent-induced neurodegenerations in cultured cells. We found that DMF and its metabolite monomethyl fumarate (MMF) attenuated oxaliplatin-, cisplatin-, and bortezomib- (but not paclitaxel-) induced inhibition of neurite outgrowth, but had no effect on cell death as a result of these agents in cultured PC12 cells and primary cultured rat dorsal root ganglion (DRG) neurons. Furthermore, Nrf2 DNA binding activity was increased by DMF and MMF in PC12 cells. These findings suggest that DMF, which activates Nrf2 pathway, has a potential protective action against chemotherapy-induced neurotoxicity, particularly neurite impairments.
Journal of Pharmacological Sciences (Amsterdam, Netherlands) published new progress about Atrophy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.
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