Nishimine, Takayuki; Fukushi, Kazunobu; Shibata, Naoyuki; Taira, Hiromi; Tokunaga, Etsuko; Yamano, Akihito; Shiro, Motoo; Shibata, Norio published the artcile< Kinetic Resolution of Allyl Fluorides by Enantioselective Allylic Trifluoromethylation Based on Silicon-Assisted C-F Bond Cleavage>, SDS of cas: 112-63-0, the main research area is kinetic resolution allyl fluoride enantioselective allylic trifluoromethylation; allyl fluorides; fluorine; kinetic resolution; organocatalysis; trifluoromethylation.
Under optimized reaction conditions, the synthesis of the target compounds was achieved by a reaction of trimethyl(trifluoromethyl)silane with Morita-Baylis-Hillman-reaction products [β-fluoro-α-(methylene)benzenepropanoic acid ester derivatives] using (9S)-(9”S)-9,9”-[1,4-phthalazinediylbis(oxy)]bis[10,11-dihydro-6′-methoxycinchonan] [i.e., (DHQD)2PHAL] as catalyst. The products thus formed included (βS)-α-methylene-β-(trifluoromethyl)benzenepropanoic acid Me ester (I), (βR)-α-methylene-β-(trifluoromethyl)benzenepropanoic acid Me ester and (βR)-β-fluoro-α-(methylene)benzenepropanoic acid Me ester, (βS)-β-fluoro-α-(methylene)benzenepropanoic acid Me ester. The corresponding enantiomers were obtained using (9S,9”S)-9,9”-[(2,5-diphenyl-4,6-pyrimidinediyl)bis(oxy)]bis[10,11-dihydro-6′-methoxycinchonan] [(DHQD)2PYR] as catalyst.
Angewandte Chemie, International Edition published new progress about Allylic alkylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics