Bour, James R.; Kariofillis, Stavros K.; Sanford, Melanie S. published the artcile< Synthesis, Reactivity, and Catalytic Applications of Isolable (NHC)Cu(CHF2) Complexes>, SDS of cas: 112-63-0, the main research area is copper difluoromethyl carbene NHC complex preparation aryl electrophile difluoromethylation; difluoromethylation aryl iodide copper NHC catalyst; difluoromethyl copper NHC complex intermediate difluoromethylation aryl electrophile; crystal structure copper NHC difluoromethyl complex; mol structure copper NHC difluoromethyl complex.
Elusive copper difluoromethyl complexes [(NHC)CuCHF2] were prepared by difluoromethylation of alkoxides [(NHC)CuOR] with difluoromethylsilane reagent, TMSCHF2; they react with arene electrophiles to give difluoromethylated substitution products. Difluoromethyl copper complexes have been proposed as key intermediates in a variety of Cu-catalyzed difluoromethylation reactions. However, studies of these putative intermediates have been impeded by the low stability of these [Cu(CHF2)] species. This report describes the synthesis of isolable N-heterocyclic carbene ligated copper(I) difluoromethyl complexes. The stoichiometric reactions of these complexes with aryl electrophiles (i.e., diaryliodonium salts, aryl iodides, and aryl bromides) are described. In addition, N-heterocyclic carbene copper(I) species are demonstrated to serve as catalysts for the cross-coupling of aryl iodides with (difluoromethyl)trimethylsilane to afford difluoromethyl arene products.
Organometallics published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.
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