Modnikova, G. A.; Titkova, R. M.; Glushkov, R. G.; Sokolova, A. S.; Silin, V. A.; Chernov, V. A. published the artcile< Amine derivatives of pyrrolo[3,2-d]pyrimidines>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is pyrrolopyrimidinamine derivative preparation structure pharmacol.
A series of 28 derivatives (I; R1 = Me, Cl, amino; R2 = Cl, amino; R3 = H, Ph; R4 = H, aminomethyl) was prepared by reactions of the chloro derivatives of pyrrolo[3,2-d]pyrimidines with an appropriate amine. Toxicity and antitumor, antibacterial, and antifungal activities of I were tested in mice, rats, and in vitro in cultures of Staphylococcus aureus, Escherichia coli, Microsporum canis, and Candida albicans. Most I had some antitumor activity against implanted sarcomas, melanomas, and carcinomas. No I was active against E. coli, M. canis, or C. albicans. Toxicity of I varied with LD50 = 50->500 mg/kg.
Khimiko-Farmatsevticheskii Zhurnal published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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