Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. as in the substitution reaction of a carboxylic acid and an alcohol. COA of Formula: C10H16O5.
Santos, Carine;Pimentel, Luiz;Canzian, Henayle;Oliveira, Andressa;Junior, Floriano;Dantas, Rafael;Hoelz, Lucas;Marinho, Debora;Cunha, Anna;Bastos, Monica;Boechat, Nubia research published 《 Hybrids of Imatinib with Quinoline: Synthesis, Antimyeloproliferative Activity Evaluation and Molecular Docking》, the research content is summarized as follows. In this context, heterocyclic systems, such as quinoline, which is present as a pharmacophore in the structure of the TKI inhibitor bosutinib (BST), was widely applied. Thus, this work aimed to obtain new hybrids of imatinib containing quinoline moieties I [R = CN, CO(O)Et; R1 = H, Cl; R2 = H, Me, MeO, CF3; R3 = H, Cl; X = Y = C, N] and evaluate them against K562 cells. The compounds were synthesized with a high purity degree. Among the produced mols., the inhibitor I [R = R1 = R2= R3 = H, X = N, Y = C] showed a suitable reduction in cell viability, with a CC50 value of 0.9μM (IMT, CC50 = 0.08μM). Mol. docking results suggest that the interaction between the most active inhibitor I [R = R1 = R2= R3 = H, X = N, Y = C] and the BCR-ABL1 enzyme occurs at the bosutinib binding site through a competitive inhibition mechanism. Despite being less potent and selective than IMT, I [R = R1 = R2= R3 = H, X = N, Y = C] is a suitable prototype for use in the search for new drugs against chronic myeloid leukemia (CML), especially in patients with acquired resistance to IMT.
COA of Formula: C10H16O5, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.
Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics