Sumiya, Tomio; Ishigaki, Mai; Oh, Keimei published the artcile< Synthesis of imidazole and indole hybrid molecules and antifungal activity against rice blast>, HPLC of Formula: 112-63-0, the main research area is Magnaporthe rice blast imidazole indole hybrid mol antifungal.
Azole and indole are parent substances of many natural and synthetic compounds with significant biol. activity. However, the biol. activity of the indole and azole conjugates are lack of investigation. In the present work, a series of hybrid mols. with imidazole and indole moiety were designed by using camalexin as a mol. scaffold. Compounds with different length of the carboxylic acid (4a-4f) were prepared The antifungal activity of this synthetic series together with the Et esters analogs (3a-3f) against Magnaporthe oryzae were determined by using agar cup plate assay. Data obtained from the structure-activity relationship studies indicated that the ester analogs displayed antifungal activity against Magnaporthe oryzae while the carboxylic acid derivatives did not. This result indicated that the carboxylic acid Et ester moiety is important to antifungal activity. Among all the synthesized compounds, we found that, at a concentration of 100 å¨ç, compound 3c displays the most potent inhibition activity with 38.8 é?2.5% on the inhibition of the diameter of the mycelial mat of Magnaporthe oryzae while the pos. control of propiconazole (10 å¨ç) was found 39.3 é?2.9%.
International Journal of Chemical Engineering and Applications published new progress about Fungicides. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.
Referemce:
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