Graf, Roderich published the artcile< 2-Methyl-5-aminopyridine and its derivatives>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is .
Details are given of the preparation of aldehydocollidine (Ger. pat. 349,184) and its oxidation to 6-methylnicotinic acid (1). The HCl salt of I and SOCl2 do not react below the b. p. of the SOCl2; at the b. p. there results an intensely green-reddish brown dye; MeOH-HCl gives the Me ester of I, m. 32é? the ester seps. on warming the aqueous solution as an oil; Et ester, b15 130é? b. 222-4é?(slight decomposition); amide, m. 194é? hydrazide (II), m. 134-5é?(benzal derivative, m. 184-5é? o-chlorobenzal derivative, m. 183-4é? vanillal derivative, m. 245-60é?; II and KNO: in N HCl give the azide (III), m. 44-5é? and sec-bis(6-metkylnicotinic acid) hydraside, m. 247-50é? III and PhNH2 in Et2O give the anilide of I, m. 134-7é? 2-methyl-5-aminopyridine and III give N-(6-methyl-3-pyridoyl)-6-methyl-3-aminopyridine, m. 275-7é?(decomposition). Boiling III in absolute EtOH gives 2-methyl-5-carbethoxyaminopyridine, m. 132-3é? while boiling H2O gives sym-bis(2-methyl-5-pyridoyl)urea, m. 285-8é?(decomposition); heating the latter with concentrated HCl at 130é?for 10 hrs. gives 2-methyl-5-aminopyridine (IV), m. 95-6é? heating III in dilute AcOH gives only a poor yield of IV; the amide (40 g.) and NaOCl give 18 g. VI. The di-HCl salt of IV m. 215-8é?(decomposition); Ac derivative, m. 122-3é? Bz derivative, m. 110-1é? IV, through the diazo solution, gives the 5-Cl derivative, b. 163é? m. 19é? oxidation gives 5-chloropyridine-2-carboxylic acid, crystals with 1 mol. H2O, m. 169-70é? chloride, m. 94é? Me ester, m. 85-7é? Ph ester, m. 92é? amide, m. 200-1é? 2-Methyl-5-bromopyridine, m. 32é? 5-bromopyridine-2-carboxylic acid, m. 175é? 2-Methyl-5-iodopyridine, m. 48-9é? HI salt, m. 235-8é? 5-iodopyridine-2-carboxylic acid, m. 188-90é? 2-Methyl-5-hydroxypyridine, m. 165-7é?
Journal fuer Praktische Chemie (Leipzig) published new progress about History. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics