Carlone, Armando; Bernardi, Luca; McCormack, Peter; Warr, Tony; Oruganti, Srinivas; Cobley, Christopher J. published the artcile< Asymmetric Organocatalysis and Continuous Chemistry for an Efficient and Cost-Competitive Process to Pregabalin>, HPLC of Formula: 112-63-0, the main research area is methyl nitropentene dimethyl malonate cinchona catalyst enantioselective conjugate addition; dimethyl methyl nitropentanyl propanedioate preparation.
The scale up development of an innovative synthetic process to pregabalin was reported. The process is underpinned by two enabling technologies critical to its success; continuous chem. allowed a safe and clean production of nitroalkene, and asym. organocatalysis gave access to the chiral intermediate in an enantioenriched form. Crucial to the success of the process was the careful development of a continuous process to nitroalkene and optimization of the organocatalyst and of the reaction conditions to attain remarkably high turn-over frequency in the catalytic asym. reaction. Successful recycle of the organocatalysts was also developed in order to achieve a cost-competitive process.
Organic Process Research & Development published new progress about Alkanes, nitro Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics