On July 23, 2009, Kurimoto, Ayumu; Katoda, Wataru; Hashimoto, Kazuki; Takahashi, Kazuhiko published a patent.Category: esters-buliding-blocks The title of the patent was Preparation of adenine compound. And the patent contained the following:
The title compounds I [A1 = (CH2)m; A2 = (CH2)n; R1 = alkyl; R2, R3 = H, alkyl; or NR2R3 = pyrrolidine, morpholine, thiomorpholine, etc.; R4 = alkyl; m, n = integer from 2 to 5] are prepared by debenzylation of II [p = 1 or 2; R = H, halo, alkyl, etc.; A1, A2, R1 – R3, m, n = as defined above], followed by reaction with alkyl (3-formylphenyl)acetate in the presence of a boron-containing reducing agent. I are useful as pharmaceuticals (no data). Thus, debenzylation of 6-(benzylamino)-2-butoxy-9-(3-[(3-morpholin-4-ylpropyl)amino]propyl)-7,9-dihydro-8H-purin-8-one, followed by reaction with Me (3-formylphenyl)acetate in the presence of sodium triacetoxyborohydride, gave Me (3-([[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-morpholin-4-ylpropyl)amino]methyl)phenyl)acetate. The experimental process involved the reaction of Methyl 2-(3-formylphenyl)acetate(cas: 142327-44-4).Category: esters-buliding-blocks
The Article related to benzylaminobutoxymorpholinylpropylaminopropyldihydropurinone debenzylation, aminobutoxyoxodihydropurinylpropylmorpholinylpropylaminomethylphenylacetate preparation, aminobutoxymorpholinylpropylaminopropyldihydropurinone reaction formylphenylacetate sodium triacetoxyborohydride and other aspects.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics