Wang, Haili; Li, Chuchu; Liu, Xiaoqing; Ma, Mingliang published the artcile< Design, synthesis and activity study of a novel PI3K degradation by hijacking VHL E3 ubiquitin ligase>, Product Details of C19H34O2, the main research area is PROTAC PI3K kinase Von Hippel Lindau degradation agent preparation; Degradation; PI3K; PROTAC; VHL.
PI3K kinase plays an important role in regulating key processes in cells, such as cell growth, metabolism, proliferation, and apoptosis. The overexpression of PI3K kinase exists in many cancers. The proteolytic target chimera (PROTAC) technol. is a new technol. that uses the ubiquitin-proteasome system to degrade a given target protein. It has been described that CRBN-based PROTAC targets the degradation of PI3K kinase. However, PROTAC based on VHL has not been reported yet. Here, the previously obtained highly active PI3K inhibitor was connected to the VHL ligand through different small mols., and obtained a series of PROTAC mols. targeting PI3K kinase. Obtain the most active compound through screening. It provides evidence for the feasibility of PROTAC technol. to recruit VHL E3 ligase in PI3K kinase.
Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.
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