369-26-6, Adding some certain compound to certain chemical reactions, such as: 369-26-6, name is Methyl 3-amino-4-fluorobenzoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 369-26-6.
To a solution of methyl 3-amino-4-fluorobenzoate (100 mg, 0.591 mmol) in DCM (3 ml) was added 4-(l-methylethyl)benzoyl chloride (162 mg, 0.887 mmol) and pyridine (96 mu, 1.18 mmol) at room temperature. The mixture was stirred for 1 h. 1 M HC1 and DCM were added and the phases were separated, the organic phase collected and the volatiles were removed in vacuo. The compound was purified by flash column chromatography. Yield: 135 mg (72percent); white solid. MS (ESI+) m/z 316 [M+H]+. HPLC purity: 99percent.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 369-26-6.
Reference:
Patent; KANCERA AB; HAMMER, Kristin; JOeNSSON, Mattias; KRUeGER, Lars; (230 pag.)WO2017/108282; (2017); A1;,
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