Stockton, Kieran P.; Greatrex, Ben W.; Taylor, Dennis K. published the artcile< Synthesis of allo- and epi-Inositol via the NHC-Catalyzed Carbocyclization of Carbohydrate-Derived Dialdehydes>, Computed Properties of 112-63-0, the main research area is Swern oxidation stereoselective cyclization benzoin triazolium carbene catalyst; inositol N heterocyclic carbene catalyst carbocyclization aldehyde cyclitol preparation.
A synthesis of carbocyclic sugars from carbohydrate-derived dialdehydes using organo-catalysis has been developed. Sorbitol, mannitol, and galactitol were converted via 1,6-tritylation, per-benzylation or permethylation, detritylation, and Swern oxidation into 2,3,4,5-tetra-O-alkyl-dialdoses that were cyclized via the benzoin reaction promoted by a triazolium carbene. Manno- and galacto-configured dialdehydes gave predominantly single inosose stereo-isomers in up to 75% yield if the mixture was acetylated prior to isolation while the gluco-dialdehyde afforded a mixture of three stereoisomers in 61% overall yield. The inososes were stereospecifically reduced using sodium borohydride and then deprotected to give allo- and epi-inositol in good yield that confirmed the structural and stereochem. assignments.
Journal of Organic Chemistry published new progress about Catalysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics