In 2019,Cogent Chemistry included an article by Al-Taweel, Samir A.; Al-Trawneh, Salah A.; Al-Trawneh, Wal’a M.. Application In Synthesis of Ethyl 3-(dimethylamino)acrylate. The article was titled 《Palladium-catalyzed amination of 2-chlorothienopyridone with primary aromatic amines》. The information in the text is summarized as follows:
A series of Et 7-cyclopropyl-2-(arylamino)-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylates I (R1 = H; R2 = H, Me, F etc,) were prepared by coupling of Et 7-cyclopropyl-2-chloro-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylate with primary aromatic amines via palladium-catalyzed amination using palladium acetate Pd(OAc)2 in the presence of cesium fluoride in good yields. 7-Cyclopropyl-2-(phenylamino)-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid showed weak activity against E.aerogenas and S.aureus bacteria. The results came from multiple reactions, including the reaction of Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2Application In Synthesis of Ethyl 3-(dimethylamino)acrylate)
Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Application In Synthesis of Ethyl 3-(dimethylamino)acrylate
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