Ruzi, Rehanguli; Liu, Kai; Zhu, Chengjian; Xie, Jin published their research in Nature Communications on December 31 ,2020. The article was titled 《Upgrading ketone synthesis direct from carboxylic acids and organohalides》.Synthetic Route of C9H8O4 The article contains the following contents:
A photoredox, nickel and phosphoranyl radical synergistic cross-electrophile coupling of com. available chems., aromatic acids RCO2H (R = 4-methylphenyl, thiophen-3-yl, naphthalen-2-yl, etc.) and aryl/alkyl bromides R1Br (R1 = 6-(trifluoromethyl)pyridin-3-yl, 2-cyanoethyl, quinolin-3-yl, etc.) was reported. This allows for concise synthesis of highly functionalized ketones RC(O)R1directly, without the preparation of activated carbonyl intermediates or organometallic compounds, and thus complements the conventional Weinreb ketone synthesis. Use of the appropriate photocatalyst, ligand amount and solvents can match the reaction rate required by any simple catalytic cycle. The practicality and synthetic robustness of the reaction are illustrated by the facile synthesis of complex ketones from readily available feedstock chems. In the experiment, the researchers used many compounds, for example, 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Synthetic Route of C9H8O4)
3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. Synthetic Route of C9H8O4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics