In 2019,Organic Chemistry Frontiers included an article by Shen, Guoli; Khan, Ruhima; Lv, Haiping; Yang, Yong; Zhang, Xia; Zhan, Yong; Zhou, Yongyun; Fan, Baomin. Application of 4248-19-5. The article was titled 《Palladium/silver co-catalyzed syn-stereoselective asymmetric ring-opening reactions of azabenzonorbornadienes with amides》. The information in the text is summarized as follows:
The first syn-stereoselective generation of 1,2-diamino dihydronaphthalene derivatives by asym. ring-opening reaction of azabenzonorbornadienes was reported. Electron-deficient amides was successfully employed as nucleophiles in the aromatic ring-opening reaction of azabenzonorbornadienes. The reaction was co-catalyzed by Pd(OAc)2 and AgBF4 with (R)-BINAP as the chiral ligand. The asym. ring-opening (ARO) products were obtained in good to high yields (up to 96%) with excellent enantioselectivities (up to 98%). In the experiment, the researchers used tert-Butyl carbamate(cas: 4248-19-5Application of 4248-19-5)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Application of 4248-19-5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics