In 2022,Liu, Zhixin; Liu, Xinyu; Yang, Shengkuan; Miao, Xiaohe; Li, Dehai; Wang, De published an article in Journal of Organic Chemistry. The title of the article was 《Titanium-Mediated aza-Nazarov Annulation for the Synthesis of N-Fused Tricycles: A General Method to Access Lamellarin Analogues》.Synthetic Route of C5H11NO2 The author mentioned the following in the article:
Fused heterocycles with nitrogen incorporation are of particular bioactive use and high importance in many research fields, especially isoquinoline-based [6/6/5] tricycles. Here, authors report a unique strategy to access multifunctional N-fused tricycles from α,β-unsaturated isoquinoline ketone and sulfonamide under mild reaction conditions. The methodol. features wide substrate tolerance, and a set of N-fused heteroarenes including quinoline, phthalazine, quinazoline, quinoxaline, and benzothiazole cores are furnished efficiently. Moreover, the protocol is easy to scale up to synthesize lamellarin analogs, and the amide group of the product is also easy to transfer to other functional groups. In the experiment, the researchers used tert-Butyl carbamate(cas: 4248-19-5Synthetic Route of C5H11NO2)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Synthetic Route of C5H11NO2
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