Name: H-Phg-OEt.HClOn March 1, 2017, Nishikawa, Yasuhiro; Nakamura, Hidetsugu; Ukai, Norimitsu; Adachi, Wakana; Hara, Osamu published an article in Tetrahedron Letters. The article was 《Tetraethylorthosilicate as a mild dehydrating reagent for the synthesis of N-formamides with formic acid》. The article mentions the following:
The synthesis of N-formamides with formic acid as a formyl source under mild conditions was achieved using tetraethylorthosilicate (TEOS), a low cost and environmentally benign reagent. The mild conditions in this system enable the formylation of a variety of amino acid derivatives including stereochem. labile phenylglycine Et ester with 96% ee. This new protocol could also be applied to simple amines including weakly basic aniline derivatives, giving various primary and secondary formamides. In the experimental materials used by the author, we found H-Phg-OEt.HCl(cas: 59410-82-1Name: H-Phg-OEt.HCl)
H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Name: H-Phg-OEt.HCl They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics