Hou, Xi-Qiang; Lin, Ye; Du, Da-Ming published an article in 2021. The article was titled 《Organocatalytic domino annulation of in-situ generated tert-butyl 2-hydroxybenzylidenecarbamates with 2-isothiocyanato-1-indanones for synthesis of bridged and fused ring heterocycles》, and you may find the article in Organic Chemistry Frontiers.Quality Control of tert-Butyl carbamate The information in the text is summarized as follows:
A one-pot efficient asym. domino annulation of 2-isothiocyanato-1-indanones with tert-Bu 2-hydroxybenzylidene carbamates in-situ generated from 2-hydroxyaryl-substituted α-amido sulfones was developed. This reaction firstly provided a powerful tool for the enantioselective construction of functionalized bridged fused ring hererocycles bearing three adjacent stereogenic centers in high yields with excellent diastereo- and enantioselectivities (up to 91% yield, >20 : 1 dr and 99% ee). In the experiment, the researchers used many compounds, for example, tert-Butyl carbamate(cas: 4248-19-5Quality Control of tert-Butyl carbamate)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Quality Control of tert-Butyl carbamate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics