Product Details of 4755-77-5In 2019 ,《A newfangled synthesis of integrase inhibitor drug substance raltegravir potassium》 appeared in Asian Journal of Chemistry. The author of the article were Rao, S. Venkat; Potluri, Vamsi Krishna; Potluri, Ramesh Babu. The article conveys some information:
Raltegravir sodium synthesis was achieved from its one of the key starting materials with retro synthetic approach, in which without using its critical starting material chem. known as 5-methyl-1,3,4-oxadiazole-2-carbonyl chloride and which is more unstable during the synthesis of raltegravir potassium. Almost all the existed literatures commonly using this starting material in its synthesis even it is having a stability issue and hence to achieve a stable and economically viable synthesis. The current research describes a new route of synthesis by constructing an oxadiazole ring in a retro synthetic manner.Ethyl oxalyl monochloride(cas: 4755-77-5Product Details of 4755-77-5) was used in this study.
Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Product Details of 4755-77-5
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics