Thompson, Alicia L. S.; Kabalka, George W.; Akula, Murthy R.; Huffman, John W. published the artcile< The conversion of phenols to the corresponding aryl halides under mild conditions>, Electric Literature of 112-63-0, the main research area is aryl triflate preparation Pd catalyzed borylation copper promoted bromination; phenol sulfonylation Pd catalyzed borylation sodium promoted iodination; halide aryl preparation.
Mild, novel procedures were developed for the syntheses of aryl halides from the corresponding phenols in modest to good yields via boronate ester intermediates. E.g., Phenol reacted with Tf2O/py/CH2Cl2 to give PhOTf intermediate which subsequently reacted with bis(neopentyl glycolato)diboron in the presence of PdCl2 catalyst/KOAc/dppf/dioxane at 80° to give a neopentylboronate ester which then reacts with NaI/chloramine-T to give PhI in 58% yield.
Synthesis published new progress about Aryl halides Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics