Blauenstein, Peter; Remy, Nathalie; Buck, Alfred; Ametamey, Simon; Haberli, Marc; Schubiger, P. August published the artcile< In vivo properties of N-(2-aminoethyl)-5-halogeno-2-pyridinecarboxamide 18F- and 123I-labeled reversible inhibitors of monoamine oxidase B>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is iodo 123 pyridinecarboxylate brain imaging; fluoro 18 pyridinecarboxylate brain imaging; brain PET single photon emission tomog; MAO inhibitor brain imaging.
The reversible and highly selective monoamine oxidase B (MAO-B) inhibitor Ro 19-6327, a picolinic acid derivative, was selected for the development of new radiopharmaceuticals, whereby in place of Cl either 123I or 18F was introduced. The resp. labeling procedures have been described earlier. In this study, some metabolic properties were investigated. Blood and urine samples were analyzed, and halogenated picolinylglycine, a more hydrophilic compound, was identified as the main metabolite. This shows that the amine is oxidized to the resp. carboxylate, but the intermediate imine or aldehyde that was proposed earlier could not be detected. First experiments with single photon emission tomog. and positron emission tomog. (PET) showed that the iodo compound can be used to investigate MAO-B in vivo while the fluoro compound is accumulated in the brain to such a low degree that no PET studies can be performed. We conclude that the main reason for the poor uptake of the fluoro compound is its lower lipophilicity as compared to the iodo compound and, to a lesser degree, its metabolism, which is similar for both compounds
Nuclear Medicine and Biology published new progress about Brain. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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