Chaulet, Charlotte; Croix, Cecile; Alagille, David; Normand, Sylvain; Delwail, Adriana; Favot, Laure; Lecron, Jean-Claude; Viaud-Massuard, Marie-Claude published the artcile< Design, synthesis and biological evaluation of new thalidomide analogues as TNF-α and IL-6 production inhibitors>, Quality Control of 112-63-0, the main research area is thalidomide analog preparation cytokine tumor necrosis factor interleukin inhibition.
Several thalidomide analogs were synthesized and compared to thalidomide and its more active analog, lenalidomide, for their ability to inhibit the production of the pro-inflammatory cytokine tumor necrosis factor (TNF)-α and interleukin (IL)-6 by LPS-activated peripheral blood mononuclear cells (PBMCs). Among these compounds, two analogs containing sulfonyl group displayed interesting downregulation of TNF-α and IL-6 production
Bioorganic & Medicinal Chemistry Letters published new progress about Amides Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics