Yu, Mei-xiang; Lei, Bo; Song, Xin; Huang, Yong-mei; Ma, Xiao-qin; Hao, Chen-xia; Yang, Wan-hua; Pan, Man-li published the artcile< Compound XiongShao Capsule ameliorates streptozotocin-induced diabetic peripheral neuropathy in rats via inhibiting apoptosis, oxidative - nitrosative stress and advanced glycation end products>, Electric Literature of 112-63-0, the main research area is compound XiongShao capsule plant extract neuroprotective agent apoptosis; nitroxidative stress diabetic peripheral neuropathy; Advanced glycation end products; BAX/BCL2–caspase-3; Compound XiongShao Capsule; Diabetic peripheral neuropathy; Oxidative – nitrosative stress.
Compound XiongShao Capsule (CXSC), a traditional herb formula, has been approved for using to treat diabetic peripheral neuropathy (DPN) by the Shanghai Food and Drug Administration, with significant efficacy in clinic. This study aimed to investigate the multidimensional pharmacol. mechanisms and synergism of CXSC against DPN in rats. The quality anal. of CXSC was performed by high-performance liquid chromatog. (HPLC) and thin-layer chromatog. Rats with DPNinduced by streptozotocin/high-fat diet for 4 wk were treated with CXSC at three doses (1.2 g/kg, 0.36 g/kg, and 0.12 g/kg), or epalrestat (15 mg/kg) daily for 8 wk continuously. During the treatment period, body weight, serum glucose levels, and nerve function, including nerve conduction velocity (NCV), and mech. and thermal hyperalgesia were tested and assessed every 4 wk. In the 13th week, the histopathol. examination in the sciatic nerve was performed using a transmission electron microscope. The expression of apoptosis-related proteins of BAX, BCL2, and caspase-3 in the sciatic nerve was examined using hematoxylin and eosin staining. The serum levels of advanced glycation end products (AGEs), oxidative-nitrosative stress biomarkers of superoxide dismutase (SOD), and nitric oxide synthase (NOS) were measured using a rat-specific ELISA kit. CXSC had no significant effect on body weight or serum glucose levels (P > 0.05), but it significantly improved mech. hyperalgesia (F5,36 = 18.24, P < 0.0001), thermal hyperalgesia (F5,36 = 8.45, P < 0.0001), and NCV (motor NCV: F5,36 = 7.644, P < 0.0001, sensory NCV: F5,36 = 12.83, P < 0.0001). Besides, it maintained myelin and axonal structure integrity, downregulated the expression of apoptosis-related proteins in the sciatic nerve tissue, reduced AGEs and NOS levels, and enhanced antioxidant enzyme SOD activities in the serum. CXSC exerted neuroprotective effects against rats with DPN through multidimensional pharmacol. mechanisms including antiapoptotic activity in the sciatic nerve and downregulation of the level of serum NOS, SOD and AGEs. Journal of Ethnopharmacology published new progress about Advanced glycosylation end products Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.
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