Matsufuji, Tetsuyoshi; Shimada, Kousei; Kobayashi, Shozo; Kawamura, Asuka; Fujimoto, Teppei; Arita, Tsuyoshi; Hara, Takashi; Konishi, Masahiro; Abe-Ohya, Rie; Izumi, Masanori; Sogawa, Yoshitaka; Nagai, Youko; Yoshida, Kazuhiro; Takahashi, Hisashi published the artcile< Discovery of novel chiral diazepines as bombesin receptor subtype-3 (BRS-3) agonists with low brain penetration>, Formula: C19H34O2, the main research area is diazepine chiral preparation bombesin receptor subtype 3 agonist; structure activity chiral diazepine bombesin receptor subtype 3 agonist; Bombesin receptor subtype-3 (BRS-3) agonists; Brain penetration; Diazepine.
The discovery and optimization of a novel series of BRS-3 agonists are described. We explored a potent BRS-3 agonist with low brain penetration to avoid an adverse effect derived from central nervous system exposure. Through the derivatization process, chiral diazepines I (R1 = iso-Bu, 2-methylpyridin-5-yl) were identified as possessing low brain penetration as well as potent in vitro activity against human and mouse BRS-3s.
Bioorganic & Medicinal Chemistry Letters published new progress about Bombesin receptor BB3 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics