Takiyama, Mikina; Matsumoto, Takashi; Sanechika, Sho; Watanabe, Junko published the artcile< Pharmacokinetic study of traditional Japanese Kampo medicine shimotsuto used to treat gynecological diseases in rats>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is shimotsuto medicine gynecol disease pharmacokinetics; Active ingredients; Blood and circulatory system; Gynecological disease; Pharmacokinetics; Shimotsuto.
Shimotsuto is a traditional Japanese Kampo medicine used to treat gynecol. diseases, such as irregular menstruation, in addition to oversensitivity to cold and chilblains. Part of the pharmacol. actions of shimotsuto is traditionally considered to be exerted by an improvement effect of the blood and the circulatory system. Multiple ingredients (e.g., catalpol and paeoniflorin) contained in shimotsuto have been reported to have pharmacol. activities on the blood and circulatory system, and thus been considered to contribute to the pharmacol. actions of shimotsuto. However, it remains unclear whether the ingredients can be absorbed into the body following oral administration of shimotsuto. The aim in the present study was to specify shimotsuto ingredient absorbed into the systemic circulation in rats. Seven candidate active ingredients (catalpol, paeoniflorin, albiflorin, ligustilide, senkyunolide A, butylphthalide, and ferulic acid) in plasma after oral administration of shimotsuto were quantified by targeted liquid chromatog.-tandem mass spectrometry (LC-MS/MS) anal. This study also performed nontargeted LC-MS/MS anal. of plasma following administration of constituent crude drugs of shimotsuto to find extensively blood-absorbed ingredients of shimotsuto. Among detected peaks in the nontargeted anal., two peaks could be identified as bergapten and 8-debenzoylpaeoniflorin, subsequently their concentrations in shimotsuto-treated rat plasma were quantified. These pharmacokinetic studies indicated that catalpol showed the highest plasma concentration following administration of shimotsuto, followed by 8-debenzoylpaeoniflorin. This study suggests that all nine ingredients are absorbed into the blood following oral administration of shimotsuto and possibly contribute to its pharmacol. action.
Journal of Natural Medicines published new progress about Blood plasma. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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