Mukherjee, Kallol; Grimblat, Nicolas; Sau, Somratan; Ghosh, Koushik; Shankar, Majji; Gandon, Vincent; Sahoo, Akhila K. published the artcile< Kinetic resolution of sulfur-stereogenic sulfoximines by Pd(II)-MPAA catalyzed C-H arylation and olefination>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is alkenylative heteroaryl enabled sulfoximine enantioselective preparation; racemic sulfoximine alkene palladium MPAA catalyst alkenylative kinetic resolution; arylative heteroaryl enabled sulfoximine enantioselective preparation; arylboronic ester sulfoximine palladium MPAA catalyst arylative kinetic resolution.
A direct Pd(II)-catalyzed kinetic resolution of heteroaryl-enabled sulfoximines through an ortho-C-H alkenylation/arylation of arenes was developed. The coordination of sulfoximine pyridyl-motif and chiral amino acid MPAA ligand to Pd(II)-catalyst controlled enantio-discriminating C(aryl)-H activation. This method provided access to a wide range of enantiomerically enriched unreacted aryl-pyridyl-sulfoximine precursors and C(aryl)-H alkenylation/arylation products in good yields with high enantioselectivity (up to >99% ee), and selectivity factor up to >200. The coordination preference of directing group, ligand effect, geometry constraints and transient six-membered concerted-metalation-deprotonation species dictate stereoselectivity; DFT studies validated this hypothesis.
Chemical Science published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics