Debasis Das; Xie, Lingzhi; Wang, Jingbing; Qiao, Dandan; Hong, Jian published the artcile< Design, Synthesis of New Pyrazolo[3,4-d]Pyrimidine Derivatives and In Vitro Evaluation of Antiproliferative Activity against Leukemia Cell Lines>, Quality Control of 112-63-0, the main research area is pyrazolopyrimidine preparation antitumor human.
A series of new pyrazolo[3,4-d]pyrimidine derivatives were designed, synthesized and evaluated against leukemia cell lines. All the compounds showed good in vitro anti-proliferative activities and some of them were 8-10 times more potent than BTK inhibitor ibrutinib. The IC50 values of promising compounds (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-bromoprop-2-en-1-one, (R,Z)-4-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-4-oxobut-2-enenitrile, (R,E)-4-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-4-oxobut-2-enenitrile were observed in the range of 0.84-2.9μM against L1210, K562 and HL-60 cell lines.
Russian Journal of Bioorganic Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics