Tsamou, Maria; Carpi, Donatella; Pistollato, Francesca; Roggen, Erwin L.; Kelly, Bakulski published the artcile< Sporadic Alzheimer's Disease- and Neurotoxicity-Related microRNAs Affecting Key Events of Tau-Driven Adverse Outcome Pathway Toward Memory Loss>, Application of C19H34O2, the main research area is microRNA tau neurotoxicity memory loss Alzheimers disease; Adverse outcome pathway; Alzheimer’s disease; key events; miRs; neurotoxicity.
A complex network of aging-related homeostatic pathways that are sensitive to further deterioration in the presence of genetic, systemic, and environmental risk factors, and lifestyle, is implicated in the pathogenesis of progressive neurodegenerative diseases, such as sporadic (late-onset) Alzheimers disease (sAD). Since sAD pathol. and neurotoxicity share microRNAs (miRs) regulating common as well as overlapping pathol. processes, environmental neurotoxic compounds are hypothesized to exert a risk for sAD initiation and progression. Literature search for miRs associated with human sAD and environmental neurotoxic compounds was conducted. Functional miR anal. using PathDip was performed to create miR-target interaction networks. The identified miRs were successfully linked to the hypothetical starting point and key events of the earlier proposed tau-driven adverse outcome pathway toward memory loss. Functional miR anal. confirmed most of the findings retrieved from literature and revealed some interesting findings. The anal. identified 40 miRs involved in both sAD and neurotoxicity that dysregulated processes governing the plausible adverse outcome pathway for memory loss. Creating miR-target interaction networks related to pathol. processes involved in sAD initiation and progression, and environmental chem.-induced neurotoxicity, resp., provided overlapping miR-target interaction networks. This overlap offered an opportunity to create an alternative picture of the mechanisms underlying sAD initiation and early progression. Looking at initiation and progression of sAD from this new angle may open for new biomarkers and novel drug targets for sAD before the appearance of the first clin. symptoms.
Journal of Alzheimer’s Disease published new progress about Actin-related protein 2/3 complex ARPC3 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.
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