Pansare, Sunil V.; Ravi, R. Gnana; Jain, Rajendra P. published the artcile< Asymmetric Allylation and Reduction on an Ephedrine-Derived Template: Stereoselective Synthesis of α-Hydroxy Acids and Derivatives>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is asym allylation reduction ephedrine derived template; hemiacetal asym conversion hydroxy acid; morpholinone asym conversion hydroxy acid; hydroxy acid asym preparation; amide hydroxy asym preparation.
A study of the diastereoselective allylation of hemiacetals I (R = Me, Et, Pr, iso-Pr; R1 = OH), derived from α-keto acids and (1R,2S)-ephedrine, was carried out. The products of allylation (I; same R; R1 = allyl), obtained as single diastereomers, were converted to α-hydroxy acid amides by treatment with Na in liquid ammonia. The amides were hydrogenated and hydrolyzed to the (R)-α-alkyl-α-hydroxy acids (>95% ee). Dehydration of the hemiacetals to enones and subsequent stereoselective hydrogenation generated the morpholinones I (same R; R1 = H) as single diastereomers. These were readily converted to (S)-α-hydroxy acids (92-96% ee).
Journal of Organic Chemistry published new progress about Allylation, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics