McGrath, Mary E.; Sprengeler, Paul A.; Hirschbein, Bernard; Somoza, John R.; Lehoux, Isabelle; Janc, James W.; Gjerstad, Erik; Graupe, Michael; Estiarte, Angeles; Venkataramani, Chandru; Liu, Yang; Yee, Robb; Ho, Joseph D.; Green, Michael J.; Lee, Chang-Sun; Liu, Liang; Tai, Vincent; Spencer, Jeffrey; Sperandio, David; Katz, Bradley A. published the artcile< Structure-Guided Design of Peptide-Based Tryptase Inhibitors>, Computed Properties of 112-63-0, the main research area is tryptase inhibitor peptide structure design preparation activity.
Improved peptide-based inhibitors of human β-tryptase were discovered using information gleaned from tripeptide library screening and structure-guided design methods, including fragment screening. These efforts sought to improve this class of inhibitors by replacing the traditional Lys or Arg P1 element. The optimized compounds display low nanomolar potency against the mast cell target and several hundred-fold selectivity with respect to serine protease off targets. Thus, replacement of Lys/Arg at P1 in a peptide-like scaffold does not need to be accompanied by a loss in target affinity.
Biochemistry published new progress about Peptides Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), BIOL (Biological Study), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics