Yan, Xiuwei; Ji, Hang; Liu, Zhihui; Ma, Shuai; Dong, Jiawei; Jiang, Xiaoyan; Hu, Xueyan; Wang, Fang; Zhao, Hongtao; Jin, Jiaqi; Zhang, Jiheng; Wang, Nan; Du, Jianyang; Hu, Shaoshan published the artcile< Characterization of the ferroptosis-related genes for prognosis and immune infiltration in low-grade glioma>, Application In Synthesis of 112-63-0, the main research area is immune microenvironment gene expression ferroptosis prognosis low grade glioma; autophagy; ferroptosis; ferroptosis-related prognostic model; hypoxia; immune microenvironment; low-grade glioma; prognostic prediction.
Although ferroptosis has been validated to play a crucial role in some types of tumors, the influence of ferroptosis-related genes (FRGs) on the immune microenvironment in low-grade glioma (LGG) remains unclear. In this research, we screen the FRGs to assess the prognosis value and immune microenvironment in LGG, to provide reliable diagnosis and treatment evidence for the clinic. A total of 1,239 patients of LGG samples were selected for subsequent analyses from The Cancer Genome Atlas, Chinese Glioma Genome Atlas, and the Repository of Mol. Brain Neoplasia Data datasets. Univariate Cox regression anal. was used to screen for prognostic FRGs. Consensus clustering was utilized to determine ferroptosis subtypes of LGG patients. Next, the prognostic model was constructed based on differentially expressed FRGs and validation in the validating datasets. The immune microenvironment, biol. pathway, and hypoxia score were explored by single-sample gene set enrichment anal. The potential response of chemotherapy and immune checkpoint blockade therapy was also estimated In addition, the correlation between the risk score and autophagy-related genes was examined by the Pearson correlation coefficient A total of three ferroptosis subtypes were identified by consensus clustering for prognostic FRGs which exhibited different outcomes, clinicopathol. characteristics, and immune microenvironment. Afterward, a prognostic model that performed great predictive ability based on nine prognostic FRGs has been constructed and validated. Moreover, the prognostic model had the potential to screen the sensitivity to chemotherapy and immunotherapy in LGG patients. Finally, we also found that the prognostic model has a great connection to autophagy and hypoxia. Conclusion: We developed a ferroptosis-related prognostic model which strongly linked to diagnosis, treatment, prognosis, and recurrence of LGG. This study also reveals the connection between ferroptosis and tumor immune microenvironment.
Frontiers in Genetics published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (BAG1). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.
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