Cicchi, Stefano; Crea, Saverio; Goti, Andrea; Brandi, Alberto published the artcile< Synthesis of new enantiopure γ-amino alcohols: their use as catalysts in the alkylation of benzaldehyde by diethylzinc>, SDS of cas: 617-55-0, the main research area is amino alc asym synthesis; dipolar cycloaddition cyclic nitrone malic acid.
The straightforward synthesis of new enantiopure γ-amino alcs. through 1,3-dipolar cycloaddition to a chiral cyclic nitrone derived from L-malic acid was described. Results of the application of these compounds as chiral catalysts in the alkylation of benzaldehyde with diethylzinc were also reported. The addition of styrene to (S)-4-(1,1-dimethylethoxy)-3,4-dihydro-2H-pyrrole 1-oxide (I), gave predominantly the adduct II which upon subsequent methylation yielded III. In the presence of III as catalyst, the addition of diethylzinc to benzaldehyde gave (R)-α-ethylbenzenemethanol in 54% enantiomeric excess.
Tetrahedron: Asymmetry published new progress about Addition reaction, stereoselective. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, SDS of cas: 617-55-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics