Flipo, Marion; Charton, Julie; Hocine, Akila; Dassonneville, Sandrine; Deprez, Benoit; Deprez-Poulain, Rebecca published the artcile< Hydroxamates: Relationships between Structure and Plasma Stability>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is hydroxamate structure plasma stability.
Hydroxamates are valuable tools for chem. biol. as well as interesting leads for medicinal chem. Although many hydroxamates display nanomolar activities against metalloproteases, only three hydroxamates have reached the market, among which is the HDAC inhibitor vorinostat. Failures in development are generally attributed to lack of selectivity, toxicity, or poor stability. To help medicinal chemists with respect to plasma stability, the authors have performed the first and preliminary study on structure-plasma stability for hydroxamates. The authors define some structural rules to predict or improve the plasma stability in the preclin. stage.
Journal of Medicinal Chemistry published new progress about Blood plasma. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics