Liu, Meina; Wang, Xingyou; Miao, Dengyun; Wang, Caiyun; Deng, Wei published the artcile< Synthesis of well-defined heteroglycopolymers via combining sequential click reactions and PPM: the effects of linker and heterogeneity on Con A binding>, Category: esters-buliding-blocks, the main research area is heteroglycopolymer sequential click reaction post polymerization modification.
Heteroglycopolymers displaying different sugar motifs have been increasingly used as tools to investigate the inherent heterogeneity in carbohydrate-protein binding to date. Herein a library of well-defined homo and hetero-glycopolymers consisting of different sugar units in the side chain were generated by reacting poly(pentafluorophenyl acrylate) (pPFPA) with difunctionalized sugar amines via post-polymerization modification, in which one class of sugar motifs is linked by the flexible thiol ether bond while the same or different sugar motifs are connected by the rigid triazole ring in the side chain. A series of difunctionalized sugar amines were synthesized by implementing sequential CuAAC and thiol-ene click reactions, which could serve as a facile methodol. for achieving heterogeneous sugar synthetic blocks with functional control. Isothermal titration calorimetry (ITC) measurements of the obtained glycopolymers with Con A as the model receptor indicated that heterogeneous glycopolymers bearing binding units D-mannose and non-binding sugar motifs in the side chains show higher affinities to Con A as compared to monoglycopolymer. More surprisingly, heterogeneous glycopolymers in which α-D-mannose is linked by the flexible thiol ether bond in the side chain showed higher binding affinity to Con A in comparison with the heterogeneous glycopolymer in which α-D-mannose is linked by the rigid triazole ring since the flexible linker could provide more spaces on the polymer.
Polymer Chemistry published new progress about Click chemistry. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Category: esters-buliding-blocks.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics