Park, Robin; Amin, Manik; Trikalinos, Nikolaos A. published the artcile< Temozolomide duration and secondary hematological neoplasms: A literature review and implications for patients with neuroendocrine neoplasms>, COA of Formula: C19H34O2, the main research area is MDS; capecitabine; leukemia; myelodysplastic syndrome; myelotoxicity.
Evidence-based recommendations for the optimal duration and sequencing of temozolomide-based treatments in advanced neuroendocrine neoplasms are lacking. Here, we conducted a systematic review of the literature for a descriptive anal. of temozolomide-associated myelodysplasias and leukemias to guide treatment planning. A database search of PubMed and Embase was conducted to identify case reports and/or case series reporting secondary myelodysplasias or leukemias in the setting of temozolomide therapy. Key data items extracted from the studies were the temozolomide dose and duration, latency to hematol. disorder, type of secondary malignancy and cytogenetics. Reported cases were summarized graphically. A total of 16 studies with 27 patient cases of therapy-related hematol. neoplasms were identified, all of which were case reports or case series. The median treatment duration and cumulative dose were 19 mo and 18,000 mg/m2, resp. Most patients (21/27) were diagnosed on, or after, 12 mo, while only one patient was diagnosed before 6 mo of treatment. Most of the patients were diagnosed, while still on treatment with temozolomide. Graphically, cases clustered around a cumulative dose of 10,000 to 30,000 mg/m2 and a latency period of 10 to 40 mo which translates to an approx. treatment duration of 12.5 to 37.5 mo. Taken together, most reported treatment-related hematol. neoplasms appear to develop on or beyond the 12-mo mark, while patients are still on treatment with temozolomide. For patients with neuroendocrine neoplasms, where sequencing of multiple therapies is important, we suggest an approach to optimizing treatment duration by establishing disease response at 6 mo before continuing further treatment and restricting treatment to or establishing closer vigilance beyond 12 mo.
Journal of Neuroendocrinology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.
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