Poulsen, Thomas B.; Bell, Mark; Jorgensen, Karl Anker published the artcile< Organocatalytic asymmetric allylic carbon-carbon bond formation>, Synthetic Route of 112-63-0, the main research area is malononitrile cycloalkylidene enantioselective Michael addition nitroalkene cinchona alkaloid catalyst; allylic carbon bond formation asym organocatalytic.
Organocatalytic allylic C-C bond-forming addition of activated alkylidenes I [X = O, CH2, CH2CH2, R1 = H; X = CH2, R1 = 7-MeO, 6-MeO, 5,7-Me2, 6,7-(MeO)2] to alkyl and aryl nitroalkenes R2CH:CHNO2 (R2 = n-pentyl, cyclohexyl, Ph, 4-MeOC6H4, 2-naphthyl, 2-thienyl, etc.) has been achieved with high diastereo- and enantioselectivity. Chiral tertiary amine catalysts are used to give allyl intermediates which exhibit γ-selectivity in the C-C bond forming step. The reactions proceed with up to >99:1 syn:anti ratio for both the alkyl- and aryl nitroalkenes with up 96% and 98% ee, resp. The products II of this conjugate addition are transformed into a range of intermediates, such as optically active conjugated dienes and 1-substituted tetralones, which are difficult to access via alternative methods.
Organic & Biomolecular Chemistry published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics