Gao, Jing; Wang, Jian; Wang, Dandan; Pan, Li; Cheng, Maosheng published the artcile< Synthesis of tert-butyl (3R,5S)-6-oxo-3,5-O-isopropylidene-3,5-dihydroxyhexanoate>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is rosuvastatin intermediate synthesis.
The title compound [i.e., 3,5-dideoxy-2,4-O-(1-methylethylidene)-L-erythro-hexuronic acid 1,1-dimethylethyl ester] was synthesized from L-(-)-malic acid by esterification, reduction, hydroxy protection, condensation, carbonyl group reduction, hydroxyl protection, deprotection and Swern oxidation with an overall yield of 25%. The title compound is a key intermediate of rosuvastatin.
Zhongguo Yiyao Gongye Zazhi published new progress about Condensation reaction. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics