Bellucci, Christina; Gualtieri, Fulvio; Chiarini, Alberto published the artcile< Negative inotropic activity of para-substituted diethyl benzylphosphonates related to fostedil. Part 3>, Related Products of 112-63-0, the main research area is benzylphosphonate diethyl preparation neg inotropic; calcium channel blocker benzylphosphonate derivative; MSBAR antihypertensive benzylphosphonate derivative; fostedil analog neg inotropic.
Di-Et benzylphosphonates 4-RC6H4CH2P(O)(OEt)2 (R = H, Me, NO2, Br, F, NH2, SO2Me, etc.), related to the calcium antagonist di-Et 4-(2-benzothiazolyl)benzylphosphonate (fostedil), produce a dose-dependent neg. inotropic effect on left atrial muscle isolated from guinea pig heart. Some of the compounds are equipotent or slightly more potent than fostedil and diltiazem taken as reference drugs. Structure-activity relationships are discussed.
European Journal of Medicinal Chemistry published new progress about Antihypertensives. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics