Sun, Bin; Dong, Yue; Lei, Kang; Wang, Jian; Zhao, Liyu; Liu, Min published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors》.COA of Formula: C10H14ClNO2 The author mentioned the following in the article:
Based on the anal. of the squalene cyclooxygenase (SE) and 14α-demethylase (CYP51) inhibitors pharmacophore feature and the dual-target active sites, a series of compounds with amide-pyridine scaffolds have been designed and synthesized to treat the increasing incidence of drug-resistant fungal infections. In vitro evaluation showed that these compounds have a certain degree of antifungal activity. The most potent compounds 11a, 11b with MIC values in the range of 0.125-2 μg/mL had a broad-spectrum antifungal activity and exhibited excellent inhibitory activity against drug-resistant pathogenic fungi. Preliminary mechanism studies revealed that the compound 11b might play an antifungal role by inhibiting the activity of SE and CYP51. Notably compounds did not show the genotoxicity through plasmid binding assay. Finally, this study of mol. docking, ADME/T prediction and the construction of 3D QSAR model were performed. These results can point out the direction for further optimization of the lead compound In the part of experimental materials, we found many familiar compounds, such as H-Phg-OEt.HCl(cas: 59410-82-1COA of Formula: C10H14ClNO2)
H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.COA of Formula: C10H14ClNO2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics