In 2018,Schulz-Fincke, Anna-Christina; Tikhomirov, Alexander S.; Braune, Annett; Girbl, Tamara; Gilberg, Erik; Bajorath, Juergen; Blaut, Michael; Nourshargh, Sussan; Guetschow, Michael published 《Design of an Activity-Based Probe for Human Neutrophil Elastase: Implementation of the Lossen Rearrangement To Induce Förster Resonance Energy Transfers》.Biochemistry published the findings.Computed Properties of C10H22N2O2 The information in the text is summarized as follows:
Human neutrophil elastase is an important regulator of the immune response and plays a role in host defense mechanisms and further physiol. processes. The uncontrolled activity of this serine protease may cause severe tissue alterations and impair inflammatory states. The design of an activity-based probe for human neutrophil elastase reported here relies on a sulfonyloxyphthalimide moiety as a new type of warhead which was linker-connected to a coumarin fluorophore. The inhibitory potency of the activity-based probe was assessed against several serine and cysteine proteases and selectivity for human neutrophil elastase (Ki = 6.85 nM) was determined The adequate fluorescent tag of the probe allowed for the in-gel fluorescence detection of human neutrophil elastase in the low nanomolar range. The coumarin moiety and the anthranilic acid function of the probe, produced in the course of a Lossen rearrangement, were part of 2 different FRETs. In the experimental materials used by the author, we found tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Computed Properties of C10H22N2O2)
Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Computed Properties of C10H22N2O2
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