《Radiosynthesis of a carbon-11 labeled PDE5 inhibitor [11C]TPN171 as a new potential PET heart imaging agent》 was written by Xu, Zhidong; Jia, Limeng; Liu, Wenqing; Li, Wei; Song, Ying; Zheng, Qi-Huang. Application In Synthesis of Methyl 3-oxovalerate And the article was included in Applied Radiation and Isotopes on August 31 ,2020. The article conveys some information:
To develop PET tracers for imaging of heart disease, a new carbon-11 labeled potent and selective PDE5 inhibitor [11C]TPN171 ([11C]9) has been synthesized. The reference standard TPN171 (9) and its corresponding precursor desmethyl-TPN171 (11) were synthesized from Me 3-oxovalerate and 2-hydroxybenzonitrile in 9 and 10 steps with 31% and 25% overall chem. yield, resp. The radiotracer [11C]TPN171 was prepared from desmethyl-TPN171 with [11C]CH3OTf through N-11C-methylation and isolated by HPLC purification followed by SPE formulation in 45-55% radiochem. yield, based on [11C]CO2 and decay corrected to EOB. The radiochem. purity was >99%, and the molar activity (Am) at EOB was in a range of 370-740 GBq/μmol.Methyl 3-oxovalerate(cas: 30414-53-0Application In Synthesis of Methyl 3-oxovalerate) was used in this study.
Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Application In Synthesis of Methyl 3-oxovalerate
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