《Asymmetric Organocatalyzed Friedel-Crafts Reaction of Trihaloacetaldehydes and Phenols》 was written by Svestka, David; Otevrel, Jan; Bobal, Pavel. Category: esters-buliding-blocksThis research focused ontrihalohydroxyalkylphenol preparation enantioselective regioselective; phenol trihaloacetaldehyde Friedel Crafts reaction organocatalyst. The article conveys some information:
Herein, the asym. organocatalyzed method for the Friedel-Crafts reaction between activated phenols and trihaloacetaldehydes was reported. A three-phase screening including 41 compounds was employed to identify a catalyst structure based on 3,5-dinitrobenzamide of 9-amino-epi-cinchonidine as the lead catalytic mol. Under the optimized reaction conditions, the above catalyst offered trihalohydroxyalkylated adducts, e.g., I in yields ranging from 26 to 92% and enantiomeric ratios within 69:31-99:1. The reaction scope was determined on 29 entries and several follow-up transformations of the enantioenriched products were accomplished. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl carbamate(cas: 4248-19-5Category: esters-buliding-blocks)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics