Li, Xin-Ran; Li, Wan-Di; Wei, Wen-Ting; Fan, Juan; Liu, Zhong-Wen; Shi, Xian-Ying published an article on February 28 ,2022. The article was titled 《Sequential Cobalt/Rhodium-Catalyzed Tandem Cyclization of Aromatic Aldehydes with Acrylates for Preparing 3-Substituted Phthalides in Oxygen Atmosphere and Neat Water》, and you may find the article in Asian Journal of Organic Chemistry.COA of Formula: C7H13NO2 The information in the text is summarized as follows:
Metal-catalyzed C-H activation/tandem reactions of aromatic acids and functionalized alkenes is profound for constructing phthalide skeleton. However, most of these reactions employ stoichiometric amounts of metal additives and metal oxidants/toxic organic solvents. Herein, a sequential cobalt/rhodium-catalyzed tandem cyclization of aromatic aldehydes and acrylates for preparing 3-substituted phthalides in one pot has been described. This protocol features the use of water as a sustainable solvent and oxygen as the singular oxidant free of any additives. The use of aromatic aldehydes instead of aromatic acids as starting materials renders this route high atom economy, and the formation of water as a sole byproduct makes this process practical and environmentally benign. After reading the article, we found that the author used Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2COA of Formula: C7H13NO2)
Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).COA of Formula: C7H13NO2
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