Hibbard, Jason P.; Yam, Jessalyn G.; Alsalek, Eyad B.; Bahamonde, Ana published an article in 2022. The article was titled 《Mild Sustainable Amide Alkylation Protocol Enables a Broad Orthogonal Scope》, and you may find the article in Journal of Organic Chemistry.Product Details of 4248-19-5 The information in the text is summarized as follows:
The development of a mild sustainable protocol to couple primary alkyl chlorides and bromides with amides was described. In contrast to current methodologies, this system does not require the use of strongly basic conditions, high temperatures or the addition of an organometallic catalyst, thereby enabling access to a remarkably orthogonal scope. K3PO4 was used to facilitate the formation of secondary and tertiary amides, which was ubiquitous scaffolds in bioactive mols. and natural products. Alkylated amide products were obtained in good to excellent yields, with no substantial limitations observed based on the steric and electronic properties of either coupling partner. In addition to this study using tert-Butyl carbamate, there are many other studies that have used tert-Butyl carbamate(cas: 4248-19-5Product Details of 4248-19-5) was used in this study.
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Product Details of 4248-19-5
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics