Wang, Yajing; Lv, Shiqun; Cao, Fangzhi; Ding, Ziwei; Liu, Jie; Chen, Qian; Gao, Jun; Huang, Xianfeng published the artcile< Investigations on the influence of the structural flexibility of nanoliposomes on their properties>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is glioblastoma nanoliposome temozolomide elasticity; Structural flexibility; cellular uptake; cytotoxicity; encapsulation efficiency; in vitro release; nanoliposomes.
In the present study, nanoliposomes with tuneable structure elasticity were prepared by reverse-phase evaporation Both Fluorescence Polarization and Fluorescence Resonance Energy Transfer was employed to characterize the structural elasticity of resultant nanoliposomes. Temozolomide, a kind of hydrophilic drug as the first-line treatment choice for glioblastoma, was encapsulated into nanoliposomes. The results showed that the flexibility of nanoliposomes gradually increased with sodium cholate, while decreasing with cholesterol, Labrafac CC and Labrafac PG adding. Furthermore, the structural flexibility of nanoliposomes was pos. correlated with the encapsulation efficiency and release rate and cellular uptake. Our research reveals the structural flexibility of nanoliposomes could affect in vitro characteristics and thereafter in vivo behaviors of nanoliposomes.
Journal of Liposome Research published new progress about Elasticity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics